“This
is truly amazing. To be able to make robust and functional mouse oocytes over
and over again entirely in a dish, and see the entire process without the
'black box' of having to do any of the steps in host animals, is most
exciting.”
Dr. Jacob Hanna, a stem
cell biologist at the Weizmann Institute of Science in Rehovot, Israel.
Cloning
humans may be coming sooner than you think. In fact, you might not even need
ova and sperm from humans.
Researchers
from Kyushu University in Japan have developed a technique to create artificial
ova from stem cells as reported in the article “Scientists
Create Fully Functional Eggs from Skin Cells”, published September 17 2016
by George Dvorsky, Gizmodo.
Their research, published in the journal Nature on the 17th of October 2016, marks the first creation of eggs entirely outside a mouse. If the process is replicated using humans, researchers could produce artificial eggs without the need for human ovaries to complete the process as noted in the article “Mouse eggs made from skin cells in a dish”, published 17 October 2016 by David Cyranoski, Nature.
The
team consists of the following scientists:
1.
Dr. Yayoi Obata, from Tokyo University
of Agriculture
2.
Dr Katsuhiko Hayashi, from Kyushu
University in Fukuoka
3.
Dr. Mitinori Saitou of the Kyoto
University
The
team, led by Dr Katsuhiko Hayashi, a reproductive biologist at Kyushu
University in Fukuoka, had finally completed the cycle of research from skin
cells to mice eggs. The original research work began when Dr Katsuhiko Hayashi
and stem-cell biologist Mitinori Saitou reprogrammed skin cells to
embryonic-like pluripotent stem cells and then into PGCs (primordial germ
cells).
PGC
need to go into ovaries to become mature eggs, so this was half of the process.
The next advance came when a team in July 2016 led by Yayoi Obata, at the Tokyo
University of Agriculture, transformed PGCs extracted from mouse fetuses into
oocytes (egg cells) without using a live mammal.
The
three (3) soon teamed up and completed the work. They did this by immersing the
PGCs in a complex chemical bath that converted the PGC's into immature egg
cells. They then added tissue taken from the ovaries of mouse fetuses, causing
the immature egg cells to mature into functional oocytes.
These
eggs were then fertilized using mice sperm in vitro and transplanted into
surrogate mice. The results speak for
themselves: twenty six (26) healthy pups born from functional eggs created in a
petri dish.
Good
to note that this process isn't 100% perfect; only 3.5% of artificial eggs gave
rise to pups, compared with 60% of eggs inside a mouse. Hayashi claims that
these mice went on to have more children of their own.
Researchers create
Artificial Mice Eggs - Human reproduction and Immortality possible without a
woman's eggs
The
implications for humans are staggering.
If
the process can be ported to human eggs, not only would it be an excellent way
to treat human infertility, but it would allow same-sex couples to have
children via a surrogate.
It
would also mean that women wouldn’t have to store their eggs or men store their
sperm; any cells from their body could be reprogrammed to become stem cells and
then be used to produce humans eggs to produce children as noted in “Japanese
Scientists Master Egg-Creation Process in Mice”, published Oct. 17, 2016 by
Robet Lee Holtz, The Wall Street Journal.
Combined
with CRISPR-Cas9 research fund by the
Government of the Netherlands as detailed in my blog article
entitled “Netherland's
Plan to create Artificial Wombs, improve invitro-fertilization and eradicate
Genetic Diseases”, this could create a whole new race of near perfect
humans, cloned from the skin cells of deceased humans using artificial wombs.
It
would also be a great way to spread human kind across the cosmos as pointed out
in my blog
article entitled “Claudius
Gros of Goethe University Frankfurt, Germany Genesis Project may be Plan B for
Earth 2.0”.
The
researchers figure it’ll take them another five to ten years to sort out the outstanding
technical issues. So immortality is coming to a clinic near you.
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